منابع مشابه
Blending block copolymer micelles in solution; Obstacles of blending.
Amphiphilic block copolymers can assemble into a variety of structures on the nanoscale in selective solvent. The micelle blending protocol offers a simple unique route to reproducibly produce polymer nanostructures. Here we expand this blending protocol to a range of polymer micelle systems and self-assembly routes. We found by exploring a range of variables that the systems must be able to re...
متن کاملAmphiphilic Block Copolymer Nano-micelles: Effect of Length Ratio of the Hydrophilic Block
Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...
متن کاملNimodipine-Loaded Pluronic Block Copolymer Micelles: Preparation, Characterization, In Vitro and In Vivo Studies
Nimodipine (NM), as a lipophilic calcium channel blocker indicated for the prevention and treatment of neurological disorders, suffers from an extensive first pass metabolism, resulting in low oral bioavailability. Polymeric micelles, self-assembled from amphiphilic polymers, have a core-shell structure which makes them unique nano-carriers with excellent performance as drug delivery. This inve...
متن کاملNimodipine-Loaded Pluronic Block Copolymer Micelles: Preparation, Characterization, In Vitro and In Vivo Studies
Nimodipine (NM), as a lipophilic calcium channel blocker indicated for the prevention and treatment of neurological disorders, suffers from an extensive first pass metabolism, resulting in low oral bioavailability. Polymeric micelles, self-assembled from amphiphilic polymers, have a core-shell structure which makes them unique nano-carriers with excellent performance as drug delivery. This inve...
متن کاملFreezing-induced ordering of block copolymer micelles.
We demonstrate here the ordering of block copolymer micelles by ice templating, below 0 °C. We used this for the preparation of silica monoliths that present an ice-templated macroporosity, combined with a 2D hexagonal mesostructure templated by the addition of P123. We propose a mechanism triggered by the progressive freezing-induced concentration.
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ژورنال
عنوان ژورنال: Kobunshi
سال: 1996
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.45.482